Study Conclusion: More than one third of patients with septic shock presented to the emergency department with vague symptoms that were not specific to infection. These patients had delayed antibiotic administration and higher risk of mortality even after controlling for demographics, illness acuity, and time-to-antibiotics in multivariate analysis. These findings suggest that the nature of presenting symptoms is an important component of sepsis clinical phenotyping and may be an important confounder in sepsis epidemiologic studies.

Citation for the Full-text Article

Filbin MR. Lynch J, Gillingham TD, Thorsen JE, Pasakarnis CL, Nepal S, Matsushima M, Rhee C, Heldt T, Reisner AT. Presenting symptoms independently predict mortality in septic shock: Importance of a previously unmeasured confounder. Critical Care Medicine. June 29, 2018. Published Online Ahead of Print. http://dx.doi.org/10.1097/CCM.0000000000003260.

Latest News from CRICO

Get all your medmal and patient safety news here.

    CRICO’s Patient Safety Leadership: A Missing Piece

    News
    Jeffrey Cooper, Professor of Anaesthesia of Harvard Medical School, was inspired to write a letter to the editor of Patient Safety and Quality Healthcare (PSQH); in response to Susan Carr's article about CRICO’s milestone 40th anniversary. Dr. Cooper highlights CRICO’s greatest achievements: its ability to convene clinical leaders from across the Harvard medical community.

    Communication Failures in Medical Malpractice – Lessons Learned From Candello

    News
    This article, co-authored by Mazen Maktabi and CRICO's Gretchen Ruoff for the American Society of Anesthesiologists publication ASA Monitor, examines how analyzing theCandello database of medical malpractice claims enables organizations to glean valuable insight as to the extent and cause of potential patient safety risks.

    Human-Machine Collaborative Optimization via Apprenticeship Scheduling

    News
    This thesis project—Human-Machine Collaborative Optimization via Apprenticeship Scheduling—was co-funded by CRICO and submitted to the Department of Aeronautics and Astronautics at Massachusetts Institute of Technology (MIT).
X
Cookies help us improve your website experience.
By using our website, you agree to our use of cookies.
Confirm